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| 1500 |
| | | Portuguese explorer Pedro Cabral, with a fleet of thirteen ships, makes landfall in Brazil | |
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| c. 1500 |
| | | The Inca empire has about 25,000 miles of well-serviced roads, designed for caravans of llamas | |
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| c. 1500 |
| | | The Portuguese establish trading posts in east Africa, on the coast of Mozambique | |
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| c. 1500 |
| | | European diseases bring death on a massive scale to an American population that has no immunity | |
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| c. 1500 |
| | | The Salic law, preventing inheritance of the throne by or through a woman, is by now accepted as a fundamental law of France | |
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| c. 1500 |
| | | In Cuzco's great temple, the sacrifices are usually of llamas, occasionally of humans | |
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| c. 1500 |
| | | Ceramic artists in Italy decorate large majolica dishes with scenes of narrative history, giving this style the name istoriato | |
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| 1501 |
| | | The 14-year-old Ismail I is enthroned as shah of a new Persian dynasty, the Safavids | |
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| 1501 |
| | | Michelangelo begins work in Florence on a tall thin slab of marble, which he transforms into David | |
|  | David Michelangelo
Fotofile CG
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| 1501 |
| | | Italian navigator Amerigo Vespucci sets sail from Lisbon to explore to the south of the New World | |
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